Scientists discover how a protein finds its way

Apr. 29, 2013 ? Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered how an enzyme co-factor can bestow specificity on a class of proteins with otherwise nonspecific biochemical activity.

The protein in question helps in the assembly of ribosomes, large macromolecular machines that are critical to protein production and cell growth. This new discovery expands scientists' view of the role of co-factors and suggests such co-factors could be used to modify the activity of related proteins and their role in disease.

"In ribosome production, you need to do things very specifically," said TSRI Associate Professor Katrin Karbstein, who led the study. "Adding a co-factor like Rrp5 forces these enzymes to be specific in their actions. The obvious possibility is that if you could manipulate the co-factor, you could alter protein activity, which could prove to be tremendously important."

The new study, which is being published the week of April 29, 2013, in the online Early Edition of the Proceedings of the National Academy of Sciences, sheds light on proteins called DEAD-box proteins, a provocative title actually derived from their amino acid sequence. These proteins regulate all aspects of gene expression and RNA metabolism, particularly in the production of ribosomes, and are involved in cell metabolism. The link between defects in ribosome assembly and cancer and between DEAD-box proteins and cancer is well documented.

The findings show that the DEAD-box protein Rok1, needed in the production of a small ribosomal subunit, recognizes the RNA backbone, the basic structural framework of nucleic acids. The co-factor Rrp5 then gives Rok1 the ability to target a specific RNA sequence by modulating the structure of Rok1.

"Despite extensive efforts, the roles of these DEAD-box proteins in the assembly of the two ribosomal subunits remain largely unknown," Karbstein said. "Our study suggests that the solution may be to identify their cofactors first."

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The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Crystal L. Young, Sohail Khoshnevis, and Katrin Karbstein. Cofactor-dependent specificity of a DEAD-box protein. PNAS, 2013 DOI: 10.1073/pnas.1302577110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/xmv1NTIqvrI/130429175906.htm

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StanChart Ghana reports 75 pct jump in Q1 profits

By Mike Collett LONDON, April 29 (Reuters) - Arsenal manager Arsene Wenger believes that if his team win their last three Premier League games they will qualify for the Champions League, but both Chelsea and Tottenham Hotspur could yet scupper his hopes. If Chelsea take at least nine points from their last four games, they will finish on 74 points. If Tottenham win their four remaining games, they would also finish on 74 points. ...

Source: http://news.yahoo.com/stanchart-ghana-reports-75-pct-jump-q1-profits-085051065.html

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Kentucky woman ordained as priest by dissident Roman Catholics

John Sommers / Reuters

Ordaining Bishop Bridget Mary Meehan (C) presents Rosemarie Smead (R), a 70-year-old Kentucky woman, to the audience after she was ordained as a Roman Catholic priest during a Celebration of Ordination at St. Andrew's United Church of Christ in Louisville, Kentucky April 27, 2013.

By Sofia Perpetua, NBC News

A dissident Roman Catholic group ordained a 70-year-old woman a priest in Louisville, Kentucky, during a ceremony attended by hundreds on Saturday.

About 150 women from all over the world have been ordained in defiance of the Roman Catholic Church that bans them from becoming priests.

Rosemarie Smead will be starting her own congregation and she told Reuters she is not worried about being excommunicated.

"It is a medieval bullying stick the bishops used to keep control over people and to keep the voices of women silent,? she said. ?I am way beyond letting octogenarian men tell us how to live our lives."

Smead, a former Carmelite nun with a bachelor's in theology and a doctorate in counseling psychology, wept throughout the ceremony.

According to a recent New York Times/CBS News poll, seventy percent of U.S. Catholics believe women should be allowed to be priests.

In a statement last week, Louisville Archbishop Joseph E. Kurtz called the planned ceremony by the Association of Roman Catholic Women Priests a "simulated ordination" in opposition to Catholic teaching.

"The simulation of a sacrament carries very serious penal sanctions in Church law, and Catholics should not support or participate in Saturday's event," Kurtz said.

Reuters contributed to this story

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b479a89/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C280C179592150Ekentucky0Ewoman0Eordained0Eas0Epriest0Eby0Edissident0Eroman0Ecatholics0Dlite/story01.htm

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Cheap iPad Minis - Business Insider

KGI Securities analyst Ming-Chi Kuo has taken a look at Apple's future and says it contains "a more affordable iPad Mini to compete with Android products," reports MacRumors.

We've heard reports of the iPad Mini having problems supporting a Retina display during manufacturing, so if Kuo's conclusion is correct, a more affordable iPad Mini makes for a nice stopgap at the next Apple event. Meanwhile, the company can take more time behind the scenes to address Retina display issues and have a nice follow-up product when all the problems are ironed out.

A $200-$250 iPad Mini would pose a nice threat as Android devices continue to gain on the company's share of the tablet market.

Source: http://www.businessinsider.com/cheap-ipad-minis-2013-4

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Best Detroit Photos & Video For Week 4/22-4/28: Dancing Boxers, Flying Octopus (SLIDESHOW)

Detroit From On High

The city looks so peaceful from above. Flickr photo <a href="http://www.flickr.com/photos/nasonurb/8672818389/sizes/o/" target="_blank">by brunosan</a>.

'The Robot'

We love this video of Downtown Youth Boxing Gym members in Detroit. As the video description says on Vimeo: <blockquote>Coach Monte does the Robot while boxers Rakeem and Branden provide the beats. Rakeems little brother Monte steals the show at the end!</blockquote>

Traditions Never Die

DETROIT, MI - APRIL 25: Zamboni Driver Al Sobotka waves an octopus thrown on the ice before a NHL game between the Nashville Predators and the Detroit Red Wings at Joe Louis Arena on April 25, 2013 in Detroit, Michigan. Photo by Dave Reginek/NHLI via Getty Images.

Cleveland Rapper Takes The Stage

Ohio rapper Machine Gun Kelly took the stage at St. Andrews Hall this week on his birthday. Though his look seems more punk Justin Bieber than rapper, the MC put on a high-energy show with some throwback twists -- see the next slide. Photo by Scott Legato/Getty Images.

Machine Gun Kelly Recreates Eminem's Performance In '8 Mile'

Before Machine Gun Kelly's show, the weather was nice enough to <a href="http://www.huffingtonpost.com/2013/04/26/machine-gun-kelly-lose-yourself-cover-acoustic-eminem_n_3162610.html" target="_blank">sit outside with fans and recreate a rap song that's nearing classic status</a>. Their sing-along version of Eminem's "Lose Yourself" and his rendition of Eminem's last battle in the movie "8 Mile" are fun, even nostalgic. And a fitting spot: St. Andrews is home to The Shelter, one of the spots that hosted Em back, back in the day.

Talk About Dedication!

And it paid off -- the Red Wings beat the Dallas Stars Saturday to advance to the playoffs. DALLAS, TX - APRIL 27: Detroit Red Wings fans show their support on the road in Dallas against the Dallas Stars at the American Airlines Center on April 27, 2013 in Dallas, Texas. Photo by Glenn James/NHLI via Getty Images.

Masonic Mishap

We've seen this photo of the Masonic Temple from Flickr user Matt Callow many times before, but we were reminded of how much we love it when the temple's plight came to light. <a href="http://www.huffingtonpost.com/2013/04/25/masonic-temple-detroit-foreclosure_n_3154429.html" target="_hplink">Wayne County took control of the historic landmark in Detroit</a> after it went into tax foreclosure with a six-figure unpaid bill. Luckily, the Masonic's owners seem to have <a href="http://www.huffingtonpost.com/2013/04/25/masonic-temple-detroit-foreclosure_n_3154429.html" target="_hplink">worked out a deal</a> to make their payments -- ones left over from 2010. But with its future uncertain, this gorgeous black and white image reminds us of just how much of a gem the Masonic is. Flickr photo <a href="http://www.flickr.com/photos/blackcustard/58080065/" target="_hplink">by Matt Callow</a>.

Detroit Symphony Orchestra In Eastern Market And More

We know this is just a commercial, but even 20 seconds of swelling music from the orchestra members, who perform in spots all around Detroit in the vid, gives us a boost. And makes us want to go see a performance!

The Lions Get Their Pick

There were plenty of pictures of Ziggy Ansah at the podium as he <a href="http://www.huffingtonpost.com/2013/04/25/ezekiel-ansah-lions-nfl-draft-2013-pick_n_3159154.html?utm_hp_ref=ap" target="_blank">became a professional football player with the Detroit Lions</a> this week, just a few years after he was first introduced to the game. But we love this less staged photo as his family captures the moment for themselves. IMAGE DISTRIBUTED FOR NIKE - Ziggy Ansah, defensive end from Brigham Young University, greets his family after being selected as the fifth overall pick by the Detroit Lions after the first round of the 2013 NFL Draft, Thursday, April 25, 2013, in New York City, New York. John Minchillo/AP Images for NIKE.

Sheefy McFly's New Video Is Definitely NSFW..

..But we love the bright colors, flashing lights and dancing bear in the new video for the Detroit rapper's expletive-laden song "Honey". To be safe, read this foreboding warning from the video's YouTube description: <blockquote>WARNING: A very small percentage of people may experience a seizure when exposed to certain visual images, including flashing lights or patterns that may appear in videos. Even people who have no history of seizures or epilepsy may have an undiagnosed condition that can cause these "photosensitive epileptic seizures" while watching videos. These seizures may have a variety of symptoms, including lightheadedness, altered vision, eye or face twitching, jerking or shaking of arms or legs, disorientation, confusion, or momentary loss of awareness. Seizures may also cause loss of consciousness or convulsions that can lead to injury from falling down or striking nearby objects. Immediately stop watching and consult a doctor if you experience any of these symptoms. Parents should watch for or ask their children about the above symptoms - children and teenagers are more likely than adults to experience these seizures. </blockquote>

Julia Solis

This week, HuffPost Detroit <a href="http://www.huffingtonpost.com/2013/04/26/abandoned-theaters-photos-julia-solis-stages-of-decay_n_3159620.html?utm_hp_ref=detroit" target="_blank">caught up with Julia Solis</a>, whose book "Stages of Decay" was released last month. It's full of photographs of theaters that have gone to ruin, which she tracks down all over the country. Pictured here is Hubert Elementary in Detroit. There's no shortage of ruins or photographers of them in the city, but we love Solis' lush, thoughtful, and playful take on the spaces going through a second life.

Brush Park Skate Park

Over in Brush Park this month, a crew has started creating a <a href="https://www.facebook.com/pages/Brush-Park-BMX/225794817545391?ref=stream&viewer_id=0" target="_blank">DIY BMX playground</a>. This shot of a rider in action comes from Angela McBride and Garret Koehler. Fittingly, Koehler is one of the organizers of Detroit's <a href="http://www.huffingtonpost.com/2013/04/01/x-games-detroit-espn-bid_n_2977837.html" target="_blank">bid to host the 2013-2015 Summer X Games</a>, ESPN's extreme sports competition.

A Basketball Player's Best Friend

A Swedish Detroit Pistons player went dog scouting in Canada and came back with Hank. That might sound odd, but the golden doodle is a cutie, and certainly a loyal companion to Jonas Jerebko. Jerebko must have picked up some tips from all time spent following coaches' commands -- Beyond being adorable, Hank is very well-trained.

This Music Video Makes Us Want To Be Kids Again

Dale Earnhardt Jr. Jr. is a local band we love, and one that's steadily catching more and more of the deserved limelight. We can't stop listening to their new EP "Patterns", but we're even more hooked on this version of their single "If You Didn't See Me (Then You Weren't on the Dance Floor". The <a href="http://www.huffingtonpost.com/2013/04/25/dale-earnhardt-jr-jr-band-video-game-remix_n_3148376.html" target="_blank">remix transforms the original into a midi song in the style of '80s video games</a> -- and the video follows suit with screencaps from dozens of old school games.

The Mind-Altering Tunnel

Every picture we stumble across of the tunnel at the DTW airport is different, and just as weirdly beautiful -- as well as a little trippy. Flickr photo <a href="http://www.flickr.com/photos/paulaltobelli/8678242939/" target="_blank">by Paul Altobelli</a>.

The Boxer

Another great video from Studio York, this one features a motivational monologue from a young Detroit boxer: <blockquote>We ask ourselves, 'Who am I to be brilliant, gorgeous and talented.' Who are you not to be? ... There's nothing enlightening about shrinking so that other people around you won't feel insecure. When we let our own light shine we ... give others the permission to do the same."</blockquote> It puts us in the mood to accomplish something grand next week.

Valverde Looks Pleased As Punch

Valverde looks like a weight has lifted off his shoulders. The closer has something to be relieved about -- in a last-minute move, the Tigers <a href="http://www.huffingtonpost.com/2013/04/24/jose-valverde-detroit-tigers-viral-twitter-contract_n_3148723.html" target="_blank">purchased his one-year minor league contract this week</a> after a disastrous end of the season with the team last year. On Saturday, he <a href="http://www.huffingtonpost.com/2013/04/27/detroit-tigers-braves-score_n_3171280.html" target="_blank">pitched a perfect 9th inning</a>. DETROIT, MI - APRIL 24: Jose Valverde #46 of the Detroit Tigers looks on after the game against the Kansas City Royals at Comerica Park on April 24, 2013 in Detroit, Michigan. The Tigers defeated the Royals 7-5. (Photo by Mark Cunningham/MLB Photos via Getty Images)

Serene City At Night

We'll never get tired of late night shots of downtown buildings. Flickr photo by <a href="http://www.flickr.com/photos/david_shane/8664624528/" target="_blank">david_shane</a>.

High Tensions

After a tense week, the Wings finally made it into the playoffs, making a record 22 seasons straight. DETROIT, MI - APRIL 25: Jimmy Howard #35 of the Detroit Red Wings makes a save on Chris Mueller #17 of the Nashville Predators while teamates Niklas Kronwall #55 and Cory Emmerton #25 defend around the net during a NHL game at Joe Louis Arena on April 25, 2013 in Detroit, Michigan. (Photo by Dave Reginek/NHLI via Getty Images)

Detroit In Photos And Video: Culture, Sports And Politics Highlights From Week Of 4/14 - 4/21

Waters Rising

Police officer Shannon Vandenheuvel, left, and Melissa Kolenda, right, help Barbara Jones from her partially submerged car in Grand Rapids, Mich. Thursday, April 18, 2013. Middle America was getting everything nature has to throw at it on Thursday, from snow in the north to tornadoes in the Plains, and with torrential rains causing floods and transportation chaos in several states.

Detroit Sends Love

A Detroit billboard said what we were all feeling this week after the bombings at the Boston Marathon on Monday. Bless you, Boston.

It's Electric

Local photog Dan Foley does it again. Foley snapped this incredible image of the Ren Cen during last night's electrical storm using his "Canon Rebel, a tripod and a busted umbrella."

Home Of The Free

A Detroit Police officer leads Detroit school board member Elena Herrada, taken from the Coleman A. Young Center after disrupting a Detroit City Council meeting in Detroit on Tuesday, April 16, 2013.

Twins?

Detroit Tigers fan Tab Waterman, right, of Portland, Ore., dressed to look like Tigers manger Jim Leyland, visits with a fellow fan before the start of a baseball game against the Seattle Mariners, Wednesday, April 17, 2013, in Seattle.

Kaleidoscope

Singer Miguel performs at Joe Louis Arena on April 17, 2013 in Detroit, Michigan.

Wheels Up!

4/20 wasn't just Record Store Day and the unofficial stoner holiday. X Games Detroit made this already celebratory day even better, announcing they were hosting a bash at Eastern Market's Shed 3. The extreme throwdown featured skaters, loud music and a premiere of the full-length X Games Detroit application video. A preview of the new bid vid was aired first at HuffPost Detroit.

Superior Strength

This photograph was shot by Michigan photographer Greg Kretovic and <a href="https://www.facebook.com/photo.php?fbid=444876605606335&set=a.114106422016690.21735.100651456695520&type=1&theater" target="_blank">shared to Facebook</a>. See more of his incredible Michigan-centric work at <a href="http://michigannaturephotos.photoshelter.com/" target="_blank">Michigannaturephotos.com</a>. "Through the blowing snow, a large Lake Superior wave comes ashore. Today's waves were pretty impressive and something you need to see/hear/feel in person. Marquette, MI - 4/19/13."

X Marks The Spot

Xiao Dong Wei performs with Wolf Smoke at the Magic Stick as part of Art X Detroit on April 14, 2013 in Detroit, Michigan.

Where's The Puck?

Calgary Flames goalie Miikka Kiprusoff, left, from Finland, reacts to a bouncing puck goal by Detroit Red Wings' Joahan Franzen as Red Wings' Damien Brunner, from Switzerland, celebrates during third period NHL action in Calgary, Alberta, Wednesday, April 17, 2013.

The Long Ride

Detroit police are scooping up homeless people downtown and dumping them in remote locations, the American Civil Liberties Union of Michigan said in a <a href="http://www.huffingtonpost.com/2013/04/18/detroit-homeless-police-aclu_n_3111725.html" target="_blank">complaint filed Thursday with the U.S. Department of Justice.</a> The ACLU said police are forcing individuals who appear homeless into police vehicles, transporting them out of town and dropping them off miles away, sometimes outside city limits.

Whole Lotta Waitin'...

44 days until Whole Foods opens in Midtown

Time Goes By

Morris Day and The Time performs at MotorCity Casino's Sound Board Theater on April 18, 2013 in Detroit, Michigan.

Storm Rolls In Thursday

Kid Rock Blasts High Ticket Prices

Kid Rock appeared on CNN''s "Piers Morgan Live" to talk his "Best Night Ever" summer tour, where tickets are going for just $20. He also spoke his mind on the high prices for Jay-Z and Justin Timberlake's "Legends of the Summer" tour. "It's garbage," <a href="http://www.huffingtonpost.com/2013/04/18/kid-rock-ticket-prices-jay-z-justin-timberlake_n_3108620.html" target="_blank">he told Piers in the clip</a>. Fans seem to be responding -- Bob Ritchie has now booked seven consecutive tour dates at DTE Energy Music Theatre this summer due to the positive response from Detroit.

Hold On

Seattle Mariners' Justin Smoak looks over as Detroit Tigers catcher Brayan Pena holds up the ball after getting Smoak out at the plate in the 14th inning of a baseball game, Wednesday, April 17, 2013, in Seattle. The Tigers beat the Mariners 2-1 in 14 innings.

Love In The D

HuffPost Detroit readers went wild this week for our photo story of <a href="http://www.huffingtonpost.com/2013/04/16/detroit-wedding-colony-club-photos_n_3084704.html?utm_hp_ref=detroit#slide=2338230" target="_blank">Detroit native Alexandra Kistner's wedding</a> to Timothy Kistner. All photos by Metro Detroit's own Adam Sparkes.

More Photos

Detroit In Photos And Video: Culture, Sports And Politics Highlights From Week Of 4/7 - 4/13

She's Got Vision

Documenting <a href="http://www.artxdetroit.com/" target="_blank">Art X Detroit</a>, photographer <a href="http://www.davelewinski.com/" target="_blank">Dave Lewinski</a> captures a stunning portrait of poet <a href="http://www.kresgeartsindetroit.org/fellowships/2012-fellows/natasha-t-miller/" target="_blank">Natasha "T" Miller</a>, one of the performers and a 2012 Kresge Performing Arts Fellow. The sculpture behind her at the Charles H. Wright Museum of African American History is by <a href="http://www.huffingtonpost.com/2012/02/27/charles-mcgee-public-art-detroit_n_1303575.html" target="_blank">Detroit artist Charles McGee</a>.

Salt-N-Pepa Still Have It

AUBURN HILLS, MI - APRIL 7: Recording artists Cheryl 'Salt' James, right, and Sandra 'Pepa' Denton of the hip hop group Salt-N-Pepa perform at halftime of a game between the Chicago Bulls and Detroit Pistons on April 7, 2013 at The Palace of Auburn Hills. Copyright 2013 NBAE. Photo by Allen Einstein/NBAE via Getty Images

Riverwalk In Spring

<a href="http://www.reddit.com/r/Detroit/comments/1c1ztu/my_son_cant_wait_for_summer_in_detroit/" target="_blank">On Reddit</a> this week, <a href="http://thomaslawrence.com/" target="_blank">photographer Thomas Lawrence</a> posted this great photo of his son Marcus at the Riverwalk under the heading, "My son can't wait for summer in Detroit." Us too, Marcus, us too.

Holocaust Day Of Remembrance

George Vine, center, hugs fellow Holocaust survivor Zygie Allweiss, after Allweiss and his family lit a candle in memory of those who were murdered by forced labor in concentration and prison camps during Yom HaShoah, a Holocaust Day of Remembrance, at the Holocaust Memorial Center in Farmington Hills, Mich., on Sunday, April 7, 2013. AP Photo/Detroit News, Elizabeth Conley

Outlandish Detroit Reporter Meets Outlandish Comedy News Host

On Tuesday, April 9, Fox 2's outlandish reporter Charlie LeDuff visited "The Colbert Report" to promote his book <a href="http://www.huffingtonpost.com/2013/02/11/charlie-leduff-book-detroit-american-autopsy_n_2661807.html" target="_blank"><em>Detroit: An American Autopsy</em></a>. "I believe the cause of death was auto exotic importation,"Colbert quipped. Best question: "Is moving back to Detroit, as it goes down the tubes, a stunt?"

Go Torii, Go!

Torii Hunter of the Detroit Tigers smiles in the dugout after hitting his 2,000 Major League Hit during the fifth inning of the game against the Toronto Blue Jays at Comerica Park on April 9, 2013 in Detroit, Michigan. The Tigers defeated the Blue Jays 7-3. Photo by Leon Halip/Getty Images

Pistons' Kyle Singler Visits Royal Oak Kids

This is adorable: Kyle Singler, of the Detroit Pistons, signs an autograph on April 11, 2013 at The Boys and Girls Club of South Oakland County in Royal Oak, Michigan. Copyright 2013 NBAE. Photo by Allen Einstein/NBAE via Getty Images

Keyshia Cole Sings In Style

Keyshia Cole performs in concert during the 'Woman to Woman' tour at The Soundboard, Motor City Casino on April 11, 2013 in Detroit, Michigan. Photo by Paul Warner/Getty Images

Looking Through

Another <a href="http://www.artxdetroit.com/" target="_blank">Art X Detroit</a> photo from <a href="http://www.davelewinski.com/" target="_blank">Dave Lewinski</a> captures <a href="http://scotthocking.com/" target="_blank">Scott Hocking's</a> exhibit at the Museum of Contemporary Art Detroit from a dreamy angle.

Matthew Stafford, Kelly Hall

Detroit Lions quarterback Matthew Stafford, center, and girlfriend Kelly Hall, right, laugh at a friend while watching an NBA basketball game between the Detroit Pistons and the Chicago Bulls, Sunday, April 7, 2013, in Auburn Hills, Mich. AP Photo/Duane Burleson

Big Sean Steps Out With New Beau

We hope the Detroit rapper is usually more charming than the face he's showing with his girlfriend Naya Rivera, an actress on "Glee." The two have been linked for awhile, but the premiere of Warner Bros. Pictures' And Legendary Pictures' '42' at TCL Chinese Theatre on April 9, 2013 in Hollywood, California <a href="http://www.huffingtonpost.com/2013/04/10/naya-rivera-big-sean-dating_n_3053734.html?ir=Detroit&ref=detroit" target="_blank">marked their first public appearance</a>. Photo by Imeh Akpanudosen/Getty Images

Second Bridge To Canada Passes Major Step

Gov. Rick Snyder, right, <a href="http://www.huffingtonpost.com/2013/04/12/detroit-bridge-to-canada-presidential-permit_n_3070103.html" target="_blank">announces the United States State Department issued a key permit to build a second bridge</a> linking the United States and Canada from Detroit to Windsor, Ontario during a news conference as Gary Doer, Ambassador of Canada to the United States of America, left, and Lisa Raitt, Canada's Labour Minister, middle, listen in Detroit. in Detroit, Friday April 12, 2013. AP Photo/Paul Sancya

Source: http://www.huffingtonpost.com/2013/04/28/best-detroit-photos-videos-of-the-week_n_3174582.html

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Novelties: In Cancer Treatment, New DNA Tools

[unable to retrieve full-text content]With new tools and tests on the market, doctors are now better prepared to sort through the genetic flaws that cause cells to become cancerous.

Source: http://www.nytimes.com/2013/04/28/business/in-cancer-treatment-new-dna-tools.html?partner=rss&emc=rss

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Waters off Northeast US coast unusually warm, says NOAA

Sea surface temperatures on the Northeast US Continental Shelf reached the highest recorded in 150 years, says an advisory issued by the?National Oceanic and Atmospheric Administration.

By Eoin O'Carroll,?Staff / April 26, 2013

A lobsterman returns an undersized lobster while checking traps in Mount Desert, Maine, in May 2012.

Robert F. Bukaty/AP/File

Enlarge

From North Carolina to Maine, the waters have been unusually warm lately.?

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This is according to the National Oceanic and Atmospheric Administration's?Northeast Fisheries Science Center, which issued an advisory today noting that sea surface temperatures in the?Northeast Shelf Large Marine Ecosystem during the second half of 2012 were the highest recorded in 150 years.

According to the advisory, sea surface temperatures in this region, which extends from Cape Hatteras to the Gulf of Maine and outward to the boundary of the continental shelf, increased dramatically to reach a record 57.2 degrees Fahrenheit, beating a previous record high in 1951. The average temperature over the past three decades has been typically lower than 54.3 degrees Fahrenheit.

The temperatures were recorded via satellite and ship-board measurements. Historical measurements, based on ship-board thermometers, date back to 1854. According to NOAA, the warming was the greatest increase on record, and one of only five?instances?when the temperature has changed by more than 1.8 degrees Fahrenheit. These drastic changes have not been noted elsewhere in the ocean basin, although in recent years global sea surface temperatures have been the highest on record.

The warmer ocean temperatures might be good news for beachgoers in the Northeast, but they could also disrupt ecosystems, along with the livelihoods that depend on them. The report notes that?black sea bass, summer flounder, longfin squid, and butterfish have been migrating northeastward. Lobsters are migrating too, but at a slower rate.

The report quotes Michael Fogarty, who heads NOAA's the Ecosystem Assessment Program:

?What these latest findings mean for the Northeast Shelf ecosystem and its marine life is unknown,? Fogarty said. ?What is known is that the ecosystem is changing, and we need to continue monitoring and adapting to these changes.?

Source: http://rss.csmonitor.com/~r/feeds/science/~3/XbLVjlBTXiQ/Waters-off-Northeast-US-coast-unusually-warm-says-NOAA

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Boston bomb suspect moved; FBI probe shifts focus

BOSTON (AP) ? Boston Marathon bombing suspect Dzhohkar Tsarnaev was moved from a hospital to a federal prison medical center while FBI agents shifted the focus of their investigation to how the deadly plot was pulled off and searched for evidence Friday in a landfill near the college he attended.

Tsarnaev, 19, was taken from Beth Israel Deaconess Medical Center, where he was recovering from a throat wound and other injuries suffered during an attempt to elude police last week, and he was transferred to the Federal Medical Center Devens, about 40 miles from Boston, the U.S. Marshals Service said. The facility, at a former Army base, treats federal prisoners.

"It's where he should be; he doesn't need to be here anymore," said Beth Israel patient Linda Zamansky, who thought his absence could reduce stress on bombing victims who have been recovering at the hospital under tight security.

The FBI's investigation of the April 15 bombing has turned from identification and apprehension of suspects to piecing together details of the plot, including how long the planning took, how it was carried out and whether anyone else knew or was involved.

A federal law enforcement official not authorized to speak on the record about the investigation told The Associated Press on the condition of anonymity on Friday that the FBI was gathering evidence regarding "everything imaginable."

FBI agents picked through a landfill near the University of Massachusetts Dartmouth, where Tsarnaev was a sophomore. FBI spokesman Jim Martin would not say what investigators were looking for.

An aerial photo in Friday's Boston Globe showed a line of more than 20 investigators, all dressed in white overalls and yellow boots, picking over the garbage with shovels or rakes.

Investigators also have continued to interview people who were close to Tsarnaev, including two young men from Kazakhstan who were students with him at UMass Dartmouth.

Azamat Tazhayakov and Dias Kadyrbayev were jailed by immigration authorities the day after Tsarnaev's capture. Kadyrbayev's lawyer, former federal prosecutor Robert Stahl, said the pair, who had partied with Tsarnaev and other students at an off-campus apartment, had nothing to do with the attack and had no idea their friend harbored any violent thoughts.

"These kids are just as shocked and horrified about what happened as everyone else," Stahl said. He said they are being held for violating their student visas by not regularly attending classes and want to return to Kazakhstan as soon as possible.

U.S. officials, meanwhile, said that the bombing suspects' mother had been added to a federal terrorism database about 18 months before the deadly attack ? a disclosure that deepens the mystery around the Tsarnaev family and marks the first time American authorities have acknowledged that Zubeidat Tsarnaeva was under investigation before the tragedy.

The news is certain to fuel questions about whether President Barack Obama's administration missed opportunities to thwart the marathon bombing, which killed three people and wounded more than 260.

Tsarnaev is charged with joining with his older brother, now dead, in setting off the shrapnel-packed pressure-cooker bombs. The brothers are ethnic Chechens from Russia who came to the United States about a decade ago with their parents. Investigators have said it appears that the brothers were angry about the U.S. wars in Afghanistan and Iraq.

Two government officials, speaking on condition of anonymity because they were not authorized to speak publicly about the investigation, said the CIA had Zubeidat Tsarnaeva's name added to the terror database along with that of her son Tamerlan Tsarnaev after Russia contacted the agency in 2011 with concerns that the two were religious militants.

About six months earlier, the FBI investigated mother and son, also at Russia's request, one of the officials said. The FBI found no ties to terrorism. Previously U.S. officials had said only that the FBI investigated Tamerlan Tsarnaev.

In an interview from Russia, Tsarnaeva said Friday that she has never been linked to terrorism.

"It's all lies and hypocrisy," she said from Dagestan. "I'm sick and tired of all this nonsense that they make up about me and my children. People know me as a regular person, and I've never been mixed up in any criminal intentions, especially any linked to terrorism."

Tsarnaeva faces shoplifting charges in the U.S. over the theft of more than $1,624 worth of women's clothing from a Lord & Taylor department store in Natick in 2012.

Earlier this week, she said she has been assured by lawyers that she would not be arrested if she traveled to the U.S., but she said she was still deciding whether to go. The suspects' father, Anzor Tsarnaev, said that he would leave Russia soon for the United States to visit one son and lay the other to rest.

A team of investigators from the U.S. Embassy in Moscow has questioned both parents in Russia this week, spending many hours with the mother in particular over two days.

Meanwhile, New York's police commissioner said the FBI was too slow to inform the city that the Boston Marathon suspects had been planning to bomb Times Square days after the attack at the race.

Federal investigators learned about the short-lived scheme from a hospitalized Dzhokhar Tsarnaev during a bedside interrogation that began Sunday night and extended into Monday morning, officials said. The information didn't reach the New York Police Department until Wednesday night.

"We did express our concerns over the lag," said police Commissioner Raymond Kelly, who with Mayor Michael Bloomberg had announced the findings on Thursday.

The FBI had no comment Friday.

___

Sullivan reported from Washington. Contributing to this report were Associated Press writers Rodrique Ngowi in Boston, Colleen Long in New York and Pete Yost and Julie Pace in Washington.

Source: http://news.yahoo.com/boston-bomb-suspect-moved-fbi-probe-shifts-focus-021629955.html

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Boeing Dreamliner Flights Resume (Voice Of America)

Share With Friends: | | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

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Intel confirms $200 Android notebooks are on the way

By Terry Daley ROME, April 27 (Reuters) - Udinese beat Cagliari 1-0 on Saturday thanks to a goal from Roberto Pereyra to move above Inter Milan into fifth place in Serie A, which brings a Europa League spot for next season. Pereyra's curling strike after 56 minutes saw Francesco Guidolin's side move up to 54 points, one ahead of Inter who visit relegation-threatened Palermo on Sunday (1300 GMT). Cagliari, who had striker Mauricio Pinilla sent off in added time, remain 10th on 42 points, two points and one place above Bologna, who drew 1-1 at Atalanta in the other early kickoff. ...

Source: http://news.yahoo.com/intel-confirms-200-android-notebooks-way-181015076.html

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&#39;Open&#39; Season in High Tech - NYTimes.com

Things must be getting really competitive in high technology. So many big competitive companies are striving to show how good they are at sharing.

In particular, they share the word ?open.? In the world of cloud computing, we now have OpenFlow switching specification; the OpenStack cloud platform; Open Compute, dedicated to efficient computing infrastructure; the Open Virtualization Alliance, to create software that makes one computer server do the work of many; and OpenDaylight, to generate similar magic on computer networks.

For good measure, there is also the Open Grid Forum, which works on large-scale corporate and scientific computing, and the Open Cloud Consortium, which backs cloud computing for scientific and medical research.

That pattern you may have noticed in the names is no accident. By calling your group ?open? in tech, you intimate that you believe in the free sharing of information to create superior products. It evokes the open source spirit that made the Linux operating system, as well as less-known Internet standards like the Apache Web server, so successful.

Just as important, for public relations purposes, it suggests that companies not in the group should be suspect, as they do not support that sharing, let-everything-be-free sensibility. If they are not outwardly open, they must be closed.

That is a useful message for a big incumbent player trying to combat an upstart that is threatening the incumbent?s business. Hewlett-Packard, Cisco Systems and Brocade, which for years made proprietary network switches, supported a recent meeting of OpenFlow. H.P. is also in the Open Virtualization, OpenStack and OpenDaylight groups. Cisco is also in OpenDaylight and the Open Cloud Consortium, while Intel is on the board of Open Compute and belongs to Open Virtualization and OpenDaylight.

There are many other such corporate affiliations throughout these groups. Among these many interests, it should be noted, the Open Cloud Initiative does not accept corporate sponsorship.

It may be, of course, that despite running large legal departments that vigilantly look after their company?s intellectual property, these multibillion-dollar companies have bought into the philosophy of open source ? that all software should be free. If so, the shareholders should probably be told.

Or, more pragmatically, it may be that the big businesses? products and services are threatened by new software-driven companies. In that case, it makes sense to donate some of the less valuable parts, collaborate together and try to swarm the upstarts with something better.

The fact that Amazon.com, the leader in public clouds, is not in any of the ?open? cloud organizations points at who the real competition is. Likewise, VMware, which significantly lowered the value of an individual server by pioneering virtualization, does not belong to Open Virtualization.

The pragmatic reading ? that the incumbents are motivated by expedience more than a desire to share ? is perfectly fine. It is business, leveraging as many people as possible in an open source project to undermine what the competition is doing.

But it would be O.K. if they were open about that, too.

Source: http://bits.blogs.nytimes.com/2013/04/26/open-season-in-high-tech/

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AltWWDC planned for same time as the "real" WWDC

Apple's Worldwide Developer Conference (WWDC) tickets sold out in minutes, but if you're going to be in San Francisco the second week of June, there's an alternative event happening that you may be interested in. AltWWDC is scheduled to take place at the same time as WWDC, and only a block away from the Moscone Center, where WWDC is held. What's more, it's free.

WWDC is the brainchild of Rob Elkin and Judy Chen, who created the event in 2012 after WWDC tickets sold out in record time. This year they're joined by Josh Michaels and Kyle Kincaid, who created two other alternative events, Intersection and IndieDevLab.

AltWWDC runs from June 10 - 14, 2013 at the downtown campus of San Francisco State University. Talks, lunch and coworking space for developers will be provided on a first-come, first-served basis. You don't need a WWDC badge to attend. So far, confirmed speakers include Mike Lee, Victor Agreda, Jr., Brett Terpstra, Brent Simmons, Saul Mora, and Steve "Scotty" Scott. More announcements are expected, so be sure to visit the site for details.

Were you disappointed with how fast WWDC tickets sold out this year? Does AltWWDC interest you?

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/7n7Gxlj5Gwk/story01.htm

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American Idol Results: Four No More?

Source: http://www.thehollywoodgossip.com/2013/04/american-idol-results-four-no-more/

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NFL group, company teaming up for brain drug test

NEW YORK (AP) ? A potential treatment for traumatic brain injuries may be tested in retired professional football players, who are the focus of concern over blows to the head.

Neuralstem, Inc., of Rockville, Md., said Wednesday it is working with the National Football League Alumni Association to study the feasibility of such a test, which would need government approval. It would involve a drug that's now in an early human trial for treating depression. In animal studies, the drug appeared to stimulate creation of brain cells.

Concern has mounted about brain injuries and disease in former NFL players, driven in part by some high-profile suicides. Thousands of former players are suing the league and its teams, saying that for years the NFL did not do enough to protect players from concussions.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-24-NFL-Brain%20Injury/id-322ea11de6264f5f806bd35c94be7a30

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Suspected child kidnapper-rapist arrested in Mexico

By Steve Gorman

LOS ANGELES (Reuters) - A convicted felon suspected in the kidnapping and rape of a 10- year-old California girl who was snatched from her bedroom last month was arrested early on Wednesday in Mexico and returned to Los Angeles, FBI officials said.

Tobias Dustin Summers, also a reputed member of a white supremacist street gang in the San Fernando Valley area of Los Angeles, was wanted on 37 criminal counts stemming from the March 27 kidnapping, the FBI said.

The girl was abducted from her home in the middle of the night, driven to various locations in two vehicles and raped before being dropped off near a hospital, according to police.

A passerby who saw her wandering barefoot with cuts and bruises outside a coffee shop watched over her until police were summoned.

Authorities did not provide details of the location and circumstances of Summers' capture, but FBI spokeswoman Lourdes Arocho in Los Angeles confirmed he had been taken into custody in Baja California by Mexican national police.

At an afternoon news conference, Los Angeles Police Chief Charlie Beck credited a $50,000 reward that was "highly publicized south of the border" with leading to a telephone tip that helped authorities pinpoint Summers' whereabouts.

The fugitive's identity was initially confirmed by his tattoos, which the FBI said included the Superman logo on his upper chest, police said.

FBI special agent Tim Delaney, who oversees the criminal division of the FBI field office in Los Angeles, said Summers was returned to Los Angeles after his arrest. Beck said he would be held in lieu of $19 million bond.

Police and the FBI declined to comment on media reports that the suspect was found at a Mexican drug rehabilitation center south of Tijuana. Beck had said about three weeks ago that Summers was seen in surveillance video images crossing a foot bridge into Mexico.

Summers, 32, was indicted earlier this month on one count each of kidnapping a minor, kidnapping to commit another crime and first-degree burglary, plus 34 counts of various sex offenses. He faces multiple life prison terms if convicted, according to the District Attorney's Office.

His accused accomplice, 29-year-old Daniel Martinez, who was charged with one count each of kidnapping and burglary, was arrested on March 31.

Police have said Summers has a lengthy criminal history and had served prison terms for robbery, kidnapping, explosives possession and theft. He was most recently released from state custody in July 2012 under a program designed to ease prison overcrowding in California.

(Reporting by Steve Gorman; Editing by Cynthia Johnston, Eric Walsh and Cynthia Osterman)

Source: http://news.yahoo.com/accused-los-angeles-child-kidnapper-rapist-arrested-mexico-003238826.html

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Michael Kors: Halle Berry Handles Pregnancy Style Fabulously

"I think the rules for pregnancy have totally changed, and if you look like Halle I think it all works."

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/ewEhxhxnrYk/

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Teens Only Slightly Influenced by Sexual Media

Watching sexy movies and TV shows or accessing sexually explicit content online may influence how teens have sex ? but only slightly, new research finds.

Teenagers in the Netherlands who watch sexually explicit media are more likely than other teens to have sex for money and to try new sexual behaviors, according to a new study published Thursday (April 25) in The Journal of Sexual Medicine. However, the links were small, accounting for only 0.3 percent to 4 percent of the differences in behaviors.

"Our data suggest that other factors such as personal dispositions ? specifically sensation-seeking ? rather than consumption of sexually explicit material may play a more important role in a range of sexual behaviors of adolescents and young adults," study researcher Gert Martin Hald, a psychologist at the University of Copenhagen, said in a statement. [10 Facts About the Teen Brain]

Hald and his colleagues surveyed 4,600 15- to 25-year-olds online about their sexual activities and the sorts of media they consumed. They found that 88 percent of men and 45 percent of women had viewed some sort of sexually explicit media, whether via television, magazines, movies or online, in the past year.

The study can't prove that the media itself caused the sexual behavior, only that teens and young adults who watch more sex-related media also tend to have more or more varied sex. This is far from the first study to find that link. One 2011 study published in the Journal of Sex Research queried American college students and also found that viewing more sexually explicit material was correlated with more casual intercourse and first sex at a younger age.

In the United States, at least, a third of teens report sexual activity by age 16, with 71 percent having a sexual experience by 18, according to research published in April in the journal Pediatrics. Older teens actually appear to be delaying sex longer than in the past, said study researcher Lawrence Finer of the Guttmacher Institute, and they are more likely to use contraceptives when they do have sex. These factors may explain the declining teen pregnancy rate, which hit a 40-year low in the United States in 2012.

Another 2006 study surveyed 12- to 14-year-olds at two points two years apart and found that the more sexual content they consumed at those ages, the more likely they were to have sex by age 16. Again, these studies could not confirm that the media caused the sexual behavior or rule out that another factor ? such as greater interest in sex in general ? was at play.

The new study suggests that a variety of factors, including personality, must be at play in determining when and how teens have sex, Hald said.

"The effects of sexually explicit media on sexual behaviors in reality need to be considered in conjunction with such factors," he said.

Follow Stephanie Pappas on Twitter?and Google+. Follow us @livescience, Facebook?& Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/teens-only-slightly-influenced-sexual-media-113038173.html

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Optimus G Pro for AT&amp;T leaks out ahead of LG's US press event

Want a glimpse of what LG may have in store for the US market come the first of May? Chances are this latest render (pictured above) from @evleaks could very turn out to be AT&T's Optimus G Pro variant. From the looks of things, not much has changed design-wise since we reviewed the 5.5-inch global model, with the removable, high-gloss backplate still sporting that sub-surface pattern first introduced on the Optimus G. Even the arrangement of the rear camera, flash and speaker appear to have remained the same -- the only noticeable difference is the AT&T globe situated none too subtly below. Whether or not LG's reworked its internals remains to be seen, but with the event now less than a week away, we'll have all the answers soon enough.

Filed under: Cellphones, Wireless, Mobile, AT&T, LG

Comments

Source: EVLeaks (Twitter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/8Y-ss_s0lJc/

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Dow slips, S&P edges up as durable goods, Apple drag

By Caroline Valetkevitch

NEW YORK (Reuters) - The Dow dipped while the S&P 500 edged up on Wednesday as a sharp drop in durable goods orders last month added to worries about slower economic activity and Apple's results disappointed investors.

Shares of Amgen dropped 6 percent to $106.03, weighing on the Nasdaq and the S&P 500 a day after the drug company reported first-quarter sales below analysts' expectations. The S&P 500 healthcare sector index <.spxhc> fell 1.2 percent and was the worst performer among the S&P's 10 sectors.

Helping to limit losses, Boeing jumped 3.4 percent to $91.13 and gave the biggest support to the Dow after the aerospace company reported earnings that beat expectations. Boeing shares rallied despite concerns about the company's 787 Dreamliner.

The market's mixed day followed gains so far this week. The S&P 500 is still up 10.8 percent for the year despite a fairly weak month so far.

Adding to market weakness, March U.S. durable goods orders slid 5.7 percent in March, the government said, marking the biggest decline in seven months. The March drop was slightly more than twice the 2.8 percent decline forecast by economists polled by Reuters.

"That doesn't surprise me a whole lot. People are maybe starting to feel the pinch of the payroll tax that took effect in January," said Bryant Evans, portfolio manager at Cozad Asset Management, in Champaign, Illinois.

Evans said it's more evidence of slow economic growth in the United States, which may likely continue the rest of the year.

The Dow Jones industrial average <.dji> was down 21.33 points, or 0.14 percent, at 14,698.13. The Standard & Poor's 500 Index <.spx> was up 1.60 points, or 0.10 percent, at 1,580.38. The Nasdaq Composite Index <.ixic> was up 0.25 of a point, or 0.01 percent, at 3,269.58.

Procter & Gamble Co , another Dow component, fell 4.8 percent to $78 after the biggest U.S. household goods manufacturer issued a profit outlook that was below expectations. It was the stock's biggest drop since January 2009, and contributed to a 1.1 percent drop in the S&P consumer staples index <.splrcs>.

Defensive shares, however, have led the S&P 500 index's gains so far this year, which has underscored views that economic activity remains painfully slow.

(Editing by Kenneth Barry and Jan Paschal)

Source: http://news.yahoo.com/wall-street-jumps-recovery-twitter-led-drop-012743441--sector.html

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New research findings open door to zinc-oxide-based UV lasers, LED devices

Apr. 23, 2013 ? Researchers from North Carolina State University have solved a long-standing materials science problem, making it possible to create new semiconductor devices using zinc oxide (ZnO) -- including efficient ultraviolet (UV) lasers and LED devices for use in sensors and drinking water treatment, as well as new ferromagnetic devices.

"The challenge of using ZnO to make these devices has stumped researchers for a long time, and we've developed a solution that uses some very common elements: nitrogen, hydrogen and oxygen," says Dr. Lew Reynolds, co-author of a paper describing the research and a teaching associate professor of materials science and engineering at NC State. "We've shown that it can be done, and how it can be done -- and that opens the door to a suite of new UV laser and LED technologies," says Dr. Judith Reynolds, a research scientist at NC State and lead author of the paper.

To make laser and LED technologies, you need both "n-type" materials and "p-type" materials. N-type materials contain an abundance of free electrons. P-type materials have "holes" that attract those free electrons. But the holes in the p-type materials have a lower energy state, which means that electrons release their excess energy in the form of light as they travel from the n-type material to the p-type material. The shedding of excess energy at the so-called "p-n junction" is what produces light in lasers and LED devices.

Researchers have been interested in using ZnO to create these devices because ZnO produces UV light, and because ZnO can be used to make devices with relatively fewer unwanted defects than other UV emitters- which means the resulting lasers or LEDs would be more energy efficient.

However, researchers had been unable to consistently produce stable p-type materials out of ZnO. Now researchers have solved that problem by introducing a specific "defect complex," via a unique set of growth and annealing procedures, in the ZnO. The defect complex looks different from a normal ZnO molecule. The zinc atom is missing and a nitrogen atom (attached to a hydrogen atom) substitutes for the oxygen atom. These defect complexes are dispersed throughout the ZnO material and serve as the "holes" that accept the electrons in p-type materials.

Not only does the research illustrate how to create p-type materials from ZnO, but the defect complex allows the ZnO p-n junction to function efficiently -- and produce UV light -- at room temperature.

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The above story is reprinted from materials provided by North Carolina State University.

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Journal Reference:

1. J. G. Reynolds, C. L. Reynolds, A. Mohanta, J. F. Muth, J. E. Rowe, H. O. Everitt, D. E. Aspnes. Shallow acceptor complexes in p-type ZnO. Applied Physics Letters, 2013; 102 (15): 152114 DOI: 10.1063/1.4802753

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/K9CYvhXShek/130423110815.htm

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Senate panel backs Obama nominee for Medicare/Medicaid chief

WASHINGTON (Reuters) - President Barack Obama's nominee to oversee Medicare and Medicaid won the backing of a key Senate panel on Tuesday, clearing the way for a vote by the full Senate that could make Marilyn Tavenner the programs' first official administrator since 2006.

The Senate Finance Committee voted unanimously to endorse Tavenner as head of the U.S. Centers for Medicare and Medicaid Services (CMS), the agency that provides health coverage to some 100 million elderly, disabled and poor Americans, while also overseeing implementation of Obama's signature healthcare reform law.

Tavenner has been running CMS as acting administrator since late 2011.

"I think she'll make a terrific administrator. One of the best," said Senator Max Baucus of Montana, the committee's Democratic chairman.

If confirmed by a full Senate vote, Tavenner would officially take the helm at a time of daunting challenges for U.S. healthcare policy. Obama's reform law is heading for full implementation on January 1 and both Medicare and Medicaid are in the political firing line for possible deficit reductions.

A nurse and former hospital company executive who also oversaw health policy in her home state of Virginia, Tavenner's private sector credentials have won vital support from Republicans. Among her backers is House of Representatives Majority Leader Eric Cantor, who introduced her at an April 9 confirmation hearing.

Tavenner vowed in hearing testimony to run the $820 billion Centers for Medicare and Medicaid Services as a business.

(Reporting by David Morgan; Editing by Gerald E. McCormick and Bill Trott)

Source: http://news.yahoo.com/senate-panel-backs-obama-nominee-medicare-medicaid-chief-145107426.html

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Parents of Boston suspect describe his Russia trip

MAKHACHKALA, Russia (AP) ? The parents of Tamerlan Tsarnaev insisted Sunday that he came to Dagestan and Chechnya last year to visit relatives and had nothing to do with the militants operating in the volatile part of Russia, with his father saying he slept a lot of the time. But the Boston bombing suspect couldn't have been immune to the attacks that savaged the region during his six-month stay.

Investigators are now focusing on the trip that Tsarnaev made to Russia in January 2012 that has raised many questions. His father said his son stayed with him in Makhachkala, the capital of Dagestan, where the family lived briefly before moving to the U.S. a decade ago. The father had only recently returned.

"He was here, with me in Makhachkala," Anzor Tsarnaev told The Associated Press in a telephone interview. "He slept until 3 p.m., and you know, I would ask him: 'Have you come here to sleep?' He used to go visiting, here and there. He would go to eat somewhere. Then he would come back and go to bed."

Tamerlan Tsarnaev, 26, and his 19-year-old brother, Dzhokhar Tsarnaev ? both ethnic Chechens ? are accused of setting off the two bombs near the finish line of the Boston Marathon on April 15 that killed three people and wounded more than 180 others. Three days later, Tamerlan died in a shootout with police, while his brother was later captured alive but wounded.

No evidence has emerged since to link Tamerlan Tsarnaev to militant groups in Russia's Caucasus. On Sunday, the Caucasus Emirate, which Russia and the U.S. consider a terrorist organization, denied involvement in the Boston attack.

A woman who works in a small shop opposite Tsarnaev's apartment building said she only saw his son during the course of one month last summer. She described him as a dandy.

"He dressed in a very refined way," Madina Abdullaeva said. "His boots were the same color as his clothes. They were summer boots, light, with little holes punched in the leather."

Anzor Tsarnaev said they also traveled to neighboring Chechnya.

"He went with me twice, to see my uncles and aunts. I have lots of them," the father said.

He said they also visited one of his daughters, who lives in the Chechen town of Urus-Martan with her husband. His son-in-law's brothers all work in the police force under Chechen leader Ramzan Kadyrov, he said.

Moscow has given Kadyrov a free hand to stabilize Chechnya following two wars between federal troops and Chechen separatists beginning in 1994, and his feared police and security forces have been accused of rampant rights abuses.

What began in Chechnya as a fight for independence has morphed into an Islamic insurgency that has spread throughout Russia's Caucasus, with the worst of the violence now in Dagestan.

In February, 2012, shortly after Tamerlan Tsarnaev's arrival in Dagestan, a four-day operation to wipe out several militant bands in Chechnya and Dagestan left 17 police and at least 20 militants dead. In May, two car bombs shook Makhachkala, killing at least 13 people and wounding about 130 more. Other bombings and shootings targeting police and other officials took place nearly daily.

The Caucasus Emirate said Sunday that its mujahedin are not fighting with the U.S.

"We are at war with Russia, which is not only responsible for the occupation of the Caucasus, but also for heinous crimes against Muslims," it said in a statement on the Kavkaz Center website.

The group suggested that Russia's secret services would have had a greater interest in carrying out the attack in Boston.

Despite the violence in Dagestan, Anzor Tsarnaev said Sunday that his son did not want to leave and had thoughts on how he could go into business. But the father said he encouraged him to go back to the U.S. and try to get citizenship. Tamerlan Tsarnaev returned to the U.S. in July.

His mother said that he was questioned upon arrival at New York's airport.

"And he told me on the phone, 'imagine, mama, they were asking me such interesting questions as if I were some strange and scary man: Where did you go? What did you do there?'" Zubeidat Tsarnaeva recalled her son telling her at the time.

When the two ethnic Chechen suspects were identified, the FBI said it reviewed its records and found that in early 2011, a foreign government ? which law enforcement officials confirmed was Russia ? had asked for information about Tamerlan Tsarnaev. The FBI said it was told that Tsarnaev was a "follower of radical Islam" and was preparing to travel to this foreign country to join unspecified underground groups.

The FBI said that it responded by interviewing Tsarnaev and family members, but found no terrorism activity.

Both parents insist that the FBI continued to monitor Tamerlan Tsarnaev and that both of their sons were set up.

Their mother went so far on Sunday to claim that the FBI had contacted her elder son after the deadly bombs exploded at the marathon. If true, it would be the first indication that the FBI considered him a suspect before Boston descended into violence on Thursday.

The FBI declined to comment publicly Sunday.

The mother's claim could not be independently confirmed, and she has made statements in the past that appeared to show a lack of full understanding of what occurred in Boston.

Investigators released photos and video of the two Tsarnaev brothers on Thursday afternoon, but at that point their identities were not known. By late that night, Tamerlan Tsarnaev was dead.

Tsarnaeva said her elder son told her by telephone that the FBI had called to inform him that they considered him a suspect and he should come in for questioning.

She said her son refused. "I told them, what do you suspect me of?" Tsarnaeva quoted her son as saying. "This is your problem and if you need me you should come to where I am."

He then told her he was going to drive his younger brother to the university, she said, speaking by telephone from Chechnya. Tsarnaeva claimed that her son later called his wife to tell her they were being chased and fired upon.

Source: http://news.yahoo.com/parents-boston-suspect-describe-russia-trip-205525143.html

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