Thursday, May 2, 2013

Supersized U.S. finale for 'The Office' but no Steve Carell

LOS ANGELES (Reuters) - Award-winning comedy "The Office" is hoping to get an extra-long episode for the series finale later this month, but Steve Carell's bumbling office manager Michael Scott won't be joining the farewell party, the producer of the TV comedy said on Wednesday.

Greg Daniels, executive producer of the U.S. mockumentary workplace comedy, said the May 16 finale will be patterned after the original British version, in which the characters reunited after becoming famous as reality TV stars.

"After attempting to beat that (British) ending in a number of different ways, we ended up doing something very similar," Daniels told reporters on a conference call, adding that he was hoping to stretch out the finale beyond its scheduled one-hour running time.

"We are trying to get more time and the network (NBC) is being very creative about scraping some more time without us having to start the finale at a weird time that will cause half the audience to miss the first 10 minutes.

"We are still hopeful of getting slightly more than one hour," he said.

The U.S. version of "The Office," which was originated by British comedian Ricky Gervais, is coming to an end after eight years. Since the departure of Carell in 2011, audiences have fallen from around 8 million at the show's height in 2007-8 to about 5 million this year.

"I think Steve felt, and I agree, that the 'Goodbye, Michael' episode was his goodbye and he didn't want to overshadow the ending that all the other characters deserved," said Daniel.

Recent episodes of the four-time Emmy Award winning comedy have seen friction in the rosy relationship of popular married couple Jim and Pam Halpert, played by John Krasinski and Jenna Fischer.

Daniels declined to give any spoilers but said suggested their future would be largely resolved before the finale.

"My hope is that people will treat the last several episodes as the finale and not force us to do everything in the last episode.

"We didn't want there to be such anxiety over Jim and Pam that you could think of nothing else in the last episode," he said.

NBC is a unit of Comcast Corp

(Reporting By Jill Serjeant; Editing by Cynthia Osterman)

Source: http://news.yahoo.com/supersized-u-finale-office-no-steve-carell-213641350.html

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Researchers look to mathematics, nature, to understand the immune system and its role in cancer

May 1, 2013 ? Can the patterns in tree branches or the meandering bends in a river provide clues that could lead to better cancer therapies? According to a new study from Virginia Commonwealth University Massey Cancer Center, these self-similar, repeating patterns in nature known as fractals help scientists better understand how the immune system is organized and may one day be used to help improve stem cell transplant outcomes in leukemia patients by predicting the probability of transplant complications.

Recently published in the journal Biology of Blood and Marrow Transplantation, the study led by Amir Toor, M.D., found a fractal pattern in the T cell repertoire of 10 unrelated stem cell transplant donors and recipients. T cells are a family of immune system cells that keep the body healthy by identifying and launching attacks against pathogens such as bacteria, viruses or cancer. T cells have small receptors that recognize antigens, which are proteins on the surface of foreign cells. Once T cells encounter a foreign cell, the antigen fits into the T cell's receptor like a key in a lock and the T cell's deadly arsenal is unleashed on the threat. Once activated, T cells divide into many clones with receptors designed to recognize and guard against that specific pathogen. Over the course of a person's life, he will develop millions of these clonal families, which make up his T cell repertoire and protect him against the many threats that exist in his unique environment.

"The technological advancements of high throughput sequencing have only recently allowed scientists to sequence the genetic material responsible for T cell repertoire. At first glance, the data looks like a chaotic jumble of information," says Toor, a hematologist in the Bone Marrow Transplant Program and researcher in the Developmental Therapeutics program at VCU Massey Cancer Center. "However, if you study a person's T cell repertoire by analyzing the DNA segments responsible for the various types of T cell receptors, you begin to notice a fractal pattern based on segment usage." Toor and his team are hopeful that this information will give them clues that will help them better understand the recovery of immune function following stem cell transplantation and possibly predict complications such as graft-versus-host disease in transplant recipients.

Much like a child can assemble Lego blocks to create a range of different models, humans have evolved a highly efficient process by which a short span of the genome called the T cell receptor locus rearranges gene fragments to create a multitude of different T cell receptor families. In this process, DNA segments known as variable (V), diversity (D) and joining (J) segments are rearranged to create the millions of T cell receptor families, or clones, that the body uses to combat disease. Similar to how the branching pattern of a tree is faithfully replicated from the trunk all the way to its farthest branches, T cells have families that are created from DNA segments branching out from one another to form a shield that provides protection from diseases.

Toor's team looked at the frequency of T cell clones bearing different V, D and J segments in stem cell transplant donors and recipients following stem cell transplantation. Using a circular diagram designed by researcher Jeremy Meier, B.S., to better visualize the arrangement of the different DNA segments, the team observed a similar fractal order in the T cell receptor families of the donors. This order was even apparent in donors of different ethnicities living on different continents. In patients who had received a stem cell transplant, Toor found that this pattern was disrupted and the patients displayed a lower level of complexity in their T cell receptor repertoire at three months after transplant, followed by a modest improvement when a full year had elapsed after transplantation.

"Attempting to restore the fractal order of a patient's T cell receptor repertoire by optimizing the stem cell transplant process could serve as a valuable therapeutic target," says Toor. "Additionally, our findings lend an insight into nature, such that even in complex biological systems bereft of physical form, mathematically determined organization is observed."

Toor and his colleagues plan to continue using high throughput sequencing of patients' T cell receptors to learn more about how the immune system recovers following stem cell transplantation. The team hopes this will give them valuable information about the effectiveness of future stem cell transplant and immunotherapy clinical trials developed in their clinic.

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Story Source:

The above story is reprinted from materials provided by Virginia Commonwealth University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jeremy Meier, Catherine Roberts, Kassi Avent, Allison Hazlett, Jennifer Berrie, Kyle Payne, David Hamm, Cindy Desmarais, Catherine Sanders, Kevin T. Hogan, Kellie J. Archer, Masoud H. Manjili, Amir A. Toor. Fractal Organization of the Human T Cell Repertoire in Health and after Stem Cell Transplantation. Biology of Blood and Marrow Transplantation, 2013; 19 (3): 366 DOI: 10.1016/j.bbmt.2012.12.004

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/sfhajT0buVY/130501091849.htm

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Wednesday, May 1, 2013

Horizon Calendar review: Check the weather at the location of your next appointment

Horizon Calendar review: Check the weather at the location of your next appointment

Horizon Calendar by Applause Code is an innovative calendar app that includes natural language parsing, a clean design, intuitive gestures, and forecasted weather associated with each of your events.

Just like the Mac OSX Calendar and the popular iPhone calendar Fantastical, Horizon Calendar uses natural language parsing when adding an event. For example, instead of meticulously adding each detail of your event, you simply type "meeting on tuesday with Rene at Starbucks from 1-2p" and Horizon will fill take care of the rest. It's incredibly fast and incredibly easy.

But Horizon takes it a step further. As you start typing "Starbucks", the locations nearby that match will pop up above the keyboard, so you can select exactly which Starbucks you're meeting at. Choosing one will help Horizon better accurately predict the weather.

Which leads me to Horizon's next awesome feature -- weather! The main view of Horizons simply lists out out your days one after another. With each day on the list, the high/low and an icon representing the weather is displayed. If you tap on the day, more details regarding the weather for each event is shown above the list of events for the day. Scrolling through the weather will scroll through your events and tapping on an event will bring up the event details and edit screen.

Horizon Calendar is also rich with gestures: slide down from the tool bar to bring down the month view, swipe to the left to delete an event, slide down from new event entry to edit the details, and rotate your phone to bring up the yearly calendar. Horizon is also integrated with Check the Weather and will launch the app when tapping the weather icon next to an event.

The good

  • Syncs with native calendar
  • Weather for all events up to 14 days out
  • Natural Language Parsing with Intelligent Lookup
  • Intuitive gestures
  • Clean design
  • Option to show date in icon badge
  • Optional night mode
  • Support for metric system

The bad

  • No custom repeat options (only every day, week, 2 weeks, month, and year)
  • Only integrates with Check the Weather. Would love to have more apps to choose from in Settings.

The bottom line

I'm not going to lie; when a developer for Horizon Calendar first contacted me, I thought "great, another calendar app", but I was pleasantly surprised with what it turned out to be. I'm actually very excited about this calendar and a little shocked to admit that it will be replacing Fantastical as my primary iPhone calendar. The addition of custom repeat options would make Horizon nearly perfect.

Seriously, if you're looking for a new calendar, definitely give Horizon Calendar a shot.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/jz5W3DIxF70/story01.htm

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FDA approves Plan B for girls as young as 15

WASHINGTON (Reuters) - The U.S. Food and Drug Administration on Tuesday said it would allow the Plan B One-Step contraceptive to be sold without a prescription to girls as young as 15 years of age.

The announcement partially reverses a December 2011 decision that prevented the sale of the emergency contraceptive to all females of reproductive age, which was also overturned by a U.S. district judge in New York on April 5. The FDA said its approval was not related to the judge's ruling.

Instead, the agency said it was responding to an amended marketing application from Teva Women's Health Inc, a unit of Plan B maker Teva Pharmaceuticals Industries Ltd. Teva originally applied to sell Plan B to all females of reproductive age, but changed its latest bid to those 15 and older after 2011. The amended application was pending when Judge Edward Korman handed down his ruling, the FDA said.

The pill known as "Plan B" has long been at the center of political and religious battles. The FDA initially approved sale of the drug to all reproductive age females, but was ordered to bar girls under 17 by U.S. Health and Human Services Secretary Kathleen Sebelius, who came under fire from women's activists who accused her of bowing to political pressure from social conservatives.

"Research has shown that access to emergency contraceptive products has the potential to further decrease the rate of unintended pregnancies," FDA Commissioner Margaret Hamburg said in a statement.

"The data reviewed by the agency demonstrated that women 15 years of age and older were able to understand how Plan B One-Step works, how to use it properly and that it does not prevent the transmission of a sexually transmitted disease."

The FDA said the product will now be labeled "not for sale to those under 15 years of age 'proof of age required' not for sale where age cannot be verified."

Product coding is designed to prompt cashiers to request and verify the customer's age. Teva has also arranged to have a security tag placed on all product cartons to prevent theft.

The U.S. Justice Department is considering the administration's next steps in the New York court case.

(Reporting by David Morgan. Editing by Andre Grenon)

Source: http://news.yahoo.com/fda-approves-plan-b-girls-young-15-231205439.html

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As combat role eases, aircraft crashes are biggest killer of U.S. troops in Afghanistan

KABUL, Afghanistan With the combat role of U.S. troops in Afghanistan tapering off, aircraft accidents emerged as the biggest killer of U.S. troops here during the first four months of the year. Since Jan. 1, 13 service members have been killed in five crashes.

U.S. troop deaths remain at their lowest levels here in recent years. The number so far this year, 33 through Tuesday, is the lowest at this point since 2008.

After air accidents, the next biggest cause of death was improvised bombs, which claimed at least eight service members. Four died from causes unrelated to combat.

In all, 42 members of the international coalition have been killed in Afghanistan this year, including three of unknown nationalities, whose deaths in an explosion in southern Afghanistan were announced Tuesday night.

Commanders with the U.S.-led coalition say the obvious reason that casualties remain low is that Afghan security forces are doing the fighting now in most parts of the country, and they?re expected to take the lead completely in the next two months

Deaths and injuries among Afghan security forces, consequently, are reaching new highs. A Ministry of Defense spokesman would release only the number of Afghan National Army deaths from Feb. 21 through the end of March, which was 107, up from 97 for the same period the previous year. U.S. military officers say large numbers of Afghan police officers also are being killed.

Civilian casualties are up sharply, too, as are estimates of the number of insurgent attacks, which soared 47 percent in the first quarter of the year compared with the same period in 2012, according to a recent report by the Afghan NGO Safety Office, which monitors violence in Afghanistan for nongovernment aid agencies.

Civilian casualties climbed almost 30 percent, with 475 people killed and 872 injured, compared with the first quarter of 2012, according to the United Nations? senior envoy in Afghanistan, Jan Kubis. Insurgents caused most of the civilian deaths.

?Afghans in the lead? means U.S. forces aren?t exposed to risk as often as they were when Americans led much of the offensive operations in Afghanistan. Hundreds of small and medium-sized outposts have been torn down or handed to Afghan forces, and many of the 66,000 remaining U.S. troops work mainly on heavily secured bases, where they focus on advising and training with large units of the Afghan security forces rather than working with front-line units on patrols and assault operations.

Casualties from so-called green-on-blue attacks ? in which Afghan forces turn on their coalition allies ? also remain low so far this year. Such attacks caused 62 deaths last year, according to the coalition. This year, though, there have been just two incidents so far, resulting in the deaths of one British and two U.S. service members.

The drop in attacks is at least partly due to several measures the coalition put into place last fall to reduce their likelihood, U.S. Army Lt. Gen. James L. Terry, the outgoing leader of the international joint command, said Tuesday in his last news conference here.

"I think we?ve come a long way in the last year in countering that threat," he said, pausing briefly to knock on the wood of his lectern. "We?re not over it, and I?m sure there will be more attempts as we look down the road."

He noted that the Taliban have threatened recently to increase their infiltration of Afghan forces to give them a chance to stage more attacks, but he said the leaders of the Afghan security forces were working diligently to reduce the chances of more.

The measures the coalition put in place include stepping up security between adjacent Afghan and coalition bases, and assigning armed "guardian angels" to stand watch when there?s interaction with Afghan security forces.

Meanwhile, such attacks have grown more common within the Afghan forces, perpetrated by those who are sympathetic to the insurgency.

There?s no particular pattern to the types of aircraft in the five crashes. They were a Black Hawk utility helicopter, an Apache attack helicopter, a small two-seat Kiowa reconnaissance helicopter, an F-16 jet fighter and a twin-engine MC-12 surveillance turboprop plane.

In each case the Taliban claimed credit, but NATO officials said all the crashes apparently were accidents. Taliban statements often prove false or wildly inflated.

On Monday, a Boeing 747 cargo plane under contract to the Department of Defense crashed on takeoff at Bagram, the largest U.S. base in Afghanistan, claiming the lives of seven civilian crew members. The massive jet had just refueled, and after it appeared to stall on takeoff, it fell inside the base?s security perimeter and burned fiercely. NATO officials said they weren?t aware of any insurgent activity at the time of the crash.

The Taliban claimed that one, too.

Source: http://www.charlotteobserver.com/2013/04/30/4013520/as-combat-role-eases-aircraft.html

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Fiat Industrial cuts 2013 outlook as southern Europe suffers

By Jennifer Clark

MILAN (Reuters) - Italian truck and tractor maker Fiat Industrial SpA cut its 2013 targets after sales in recession-hit Europe continued to fall, pushing its truck unit to a first-quarter loss that missed analysts' expectations.

The company, which competes with Caterpillar Inc and Deere & Co , said on Tuesday it now sees truck sales in the European market falling by between 5 percent and 10 percent in 2013, slashing a forecast made as recently as January that the truck market would be flat this year.

Fiat Industrial shares slumped 5.3 percent by the close, making the stock the worst performer in the FTSE MIB blue-chip index and more than wiping out its gains of the past four sessions.

Robust sales of Case New Holland's huge, high-margin tractors and harvesting combines could not offset declines in trucks and construction equipment, as building and freight hauling withered still further in an uncertain economy.

Revenue at truck unit Iveco, which accounts for about one third of group sales, fell 4 percent to 1.82 billion euros, pushing Iveco to a trading loss of 9 million euros compared with a profit of 63 million a year ago.

"Iveco's strongest markets are the ones in southern Europe that are suffering the most," said Chairman Sergio Marchionne on a conference call, adding that the truck market hit the bottom in the first quarter.

Analysts were expecting a trading profit at Iveco of 55 million euros.

BELOW FORECAST

Fiat Industrial said it saw full-year revenue growing by between 3 and 4 percent, down from a previous forecast of a 5 percent increase. Group trading profit was 411 million euros in the first quarter, below the 435 million expected by an analysts' consensus published on the company's website.

Fiat Industrial added in a statement that it saw net industrial debt at between 1.4 and 1.6 billion euros this year, up from the range of 1.1 to 1.4 billion euros it forecast at the end of January.

At its agriculture and construction equipment arm CNH, net revenue was flat at 3.79 billion euros, while trading profit rose to 411 million euros from 368 million. All of that growth came from farm equipment, where sales rose 8.3 percent.

Construction equipment sales plummeted 26.9 percent as demand slowed in every region, the company said.

Fiat Industrial plans to merge with U.S. unit CNH later this year to create the world's third-largest capital goods maker. Merger plans are on track, Marchionne said, saying he expects to call the shareholders' meetings necessary to approve the merger in May.

"We are in the process of filing with SEC (Securities and Exchange Commission)," he said, adding the merged company plans to list its shares in the United States in the third quarter of this year. It will have dual U.S.-Italy stock market listing.

(Editing by Helen Massy-Beresford and David Holmes)

Source: http://news.yahoo.com/fiat-industrial-cuts-2013-outlook-southern-europe-suffers-180224767.html

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Wanted: Polar bear spotter on Norwegian islands

OSLO, Norway (AP) ? Do you enjoy the outdoors and have strong vocal cords? If so, Norway might have a summer job for you: three weeks in the Arctic wilderness spotting polar bears.

The governor's office on the remote northern islands of Svalbard is seeking a polar bear spotter to warn researchers doing projects in the region.

The job starts July 8 and also requires previous experience with the outdoors, good polar bear spotting skills and a competence with firearms. But Helge Solli from the governor's office says the successful candidate likely won't have to use a gun "just as long as they have a loud voice" to scare off any bears.

There are an estimated 3,000 polar bears in the Svalbard archipelago, which has a human population of about 2,400.

Source: http://news.yahoo.com/wanted-polar-bear-spotter-norwegian-islands-141318515.html

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